Disease resources

Chronic lymphocytic leukemia (CLL) is a life-threatening cancer of adults. It is a type of mature B-cell malignancy in which abnormal leukemic B lymphocytes (a type of white blood cell) arise from the bone marrow and flood peripheral blood, bone marrow, and lymphoid tissues.^1,2 Since both CLL and SLL start the same way, they are considered the same disease but occur in different body parts.²

• Fatigue
• Anemia (decreased red blood cell count)
• Lymph node enlargement
• Thrombocytopenia (decreased platelet count)
• Low-grade fever
• Unexplained weight loss
• Night sweats
• Feeling of fullness (due to an enlarged spleen or liver)
• Infection of skin, lungs, kidneys, or other organs because of low immunoglobulin levels and decreased neutrophil counts

• Accounts for 1 in 3 new cases of leukemia in the US and about 1% of cancers overall¹
• 22,760 new cases estimated in 2026¹
• 4350 deaths estimated in 2026¹
• 63% higher mean total healthcare costs among patients with a CLL diagnosis compared to those without a CLL diagnosis^7,a
• $101,122 total healthcare costs per patient per year in CLL (patients received 1L+)⁸

Follicular lymphoma (FL) is a slow-growing cancer that occurs when abnormal B cells group together in clusters called “follicles” inside lymph nodes or other tissues. It often spreads to the bone marrow and spleen, but it usually doesn’t affect organs and tissues other than the lymph nodes.¹

• Painless swelling in the neck, armpit, or groin
• Fever that no infection or other illness is causing
• Unexplained weight loss
• Sweating and chills
• Fatigue

• 2.4 new cases per 100,000 men and women per year
• 0.4 deaths per 100,000 men and women per year
• 5-year relative survival rate of 89%

Mantle cell lymphoma (MCL) develops in B cells located in the mantle zones of the lymph nodes. While MCL often starts as a slow-growing cancer, once it progresses, it can become more aggressive and grow rapidly. In advanced forms of this disease, cancer spreads from the lymph nodes to the bloodstream, bone marrow, digestive system, and/or other organs.^1,2

• Swelling in one or more lymph nodes, particularly in the neck, armpit, or groin
• Fever
• Pressure or pain in the lower back
• Belly pain
• Night sweats
• Weight loss
• Headaches, dizziness and confusion

• MCL is a rare subtype of B-cell NHL, representing 3% to 10% of all NHLs^4,5
• Annual incidence between 0.5 and 1 case per 100,000^4,6
• The median survival for patients with MCL is approximately 5 years⁷

Marginal zone lymphoma (MZL) is a slow-growing blood cancer that develops in the parts of a lymph node called the marginal zones, which wrap around the mantle zones. When a person has MZL, the B cells in the marginal zone change, or mutate, causing them to behave abnormally and multiply excessively. There are 3 types of MZL¹:

• Extranodal MZL of mucosa-associated lymphoid tissue (MALT): the most common type of MZL; develops in the stomach lining (gastric MALT) or in the lungs, skin, thyroid, salivary gland, or bowels or near your eye (nongastric MALT)
• Nodal MZL: affects the lymph nodes but can appear in the bone marrow
• Splenic MZL: affects the spleen, blood, and bone marrow

• Fever without infection
• Night sweats
• Unexplained weight loss

• MZL represents 10.5% to 11.8% of all non-Hodgkin lymphomas (NHLs), with significant variability in incidence by geographic region²
  • In 2020, there were an estimated 544,000 new cases of NHLs globally³
• In the United States, the annual incidence rate is 19.6 per 1 million⁴
• About 7460 people are newly diagnosed each year⁴
• 5-year overall survival rate of 89.8%⁴

Waldenström macroglobulinemia starts when a person’s B cells produce an abnormal lymphocyte-plasma hybrid cell, called a lymphoplasmacytic cell. These abnormal cells make large amounts of a certain type of antibody (immunoglobulin M, or IgM), which has a large and bulky structure. This causes blood to become very thick, impacting its flow through the body. As the abnormal cells multiply, it can overwhelm the bone marrow, leading to a shortage of healthy blood cells.¹

• Fever
• Night sweats
• Weight loss
• Numbness, or “pins and needles”
• Enlargement of the lymph nodes, spleen, and liver
• Central nervous symptoms
• Bleeding from the mouth or nose

• WM affects an estimated 3.8 million people per year worldwide³
• About 1000 to 1500 people are diagnosed with WM each year in the United States¹
• Average age of diagnosis is 70¹
• 5-year overall survival rate of 78%¹